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Helicase-mediated changes in RNA structure at the single-molecule level


König, S L B; Linayage, P S; Sigel, Roland K O; Rueda, D (2013). Helicase-mediated changes in RNA structure at the single-molecule level. RNA biology, 10(1):133-148.

Abstract

RNA helicases are a diverse group of RNA-dependent ATPases known to play a large number of biological roles inside the cell, such as RNA unwinding, remodeling, export and degradation. Understanding how helicases mediate changes in RNA structure is therefore of fundamental interest. The advent of single-molecule spectroscopic techniques has unveiled with unprecedented detail the interplay of RNA helicases with their substrates. In this review, we describe the characterization of helicase-RNA interactions by single-molecule approaches. State-of-the-art techniques are presented, followed by a discussion of recent advancements in this exciting field.

Abstract

RNA helicases are a diverse group of RNA-dependent ATPases known to play a large number of biological roles inside the cell, such as RNA unwinding, remodeling, export and degradation. Understanding how helicases mediate changes in RNA structure is therefore of fundamental interest. The advent of single-molecule spectroscopic techniques has unveiled with unprecedented detail the interplay of RNA helicases with their substrates. In this review, we describe the characterization of helicase-RNA interactions by single-molecule approaches. State-of-the-art techniques are presented, followed by a discussion of recent advancements in this exciting field.

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3 citations in Web of Science®
7 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:January 2013
Deposited On:08 Aug 2013 12:16
Last Modified:19 Nov 2016 08:04
Publisher:Landes Bioscience
ISSN:1547-6286
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.4161/rna.23507
PubMed ID:23353571

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