Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Henneke, G; Koundrioukoff, S; Hübscher, U (2003). Multiple roles for kinases in DNA replication. EMBO Reports, 4(3):252-256.

Full text not available from this repository.

Abstract

DNA replication is carried out by the replisome, which includes several proteins that are targets of cell-cycle-regulated kinases. The phosphorylation of proteins such as replication protein A, DNA polymerase-alpha and -delta, replication factor C, flap endonuclease 1 and DNA ligase I leads to their inactivation, suggesting that phosphorylation is important in the prevention of re-replication. Moreover, the phosphorylation of several of these replication proteins has been shown to block their association with the 'moving platform'-proliferating cell nuclear antigen. Therefore, phosphorylation seems to be a crucial regulator of replisome assembly and DNA replication, although its precise role in these processes remains to be clarified.

Item Type:Journal Article, refereed
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Biochemistry and Molecular Biology
DDC:570 Life sciences; biology
Language:English
Date:1 March 2003
Deposited On:11 Feb 2008 12:18
Last Modified:28 Nov 2013 01:35
Publisher:Nature Publishing Group
ISSN:1469-221X
Publisher DOI:10.1038/sj.embor.embor774
PubMed ID:12634841
Citations:Web of Science®. Times Cited: 22
Google Scholar™
Scopus®. Citation Count: 24

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page