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In situ sensing of single binding events by localized surface plasmon resonance


Sannomiya, T; Hafner, C; Voros, J (2008). In situ sensing of single binding events by localized surface plasmon resonance. Nano Letters, 8(10):3450-3455.

Abstract

Single binding events of nanoparticle-labeled DNA strands were detected as stepwise peak shifts in localized surface plasmon resonance by single particle measurement. We confirmed the number of binding events by observing label particles by scanning electron microscopy. Our simulation based on a multiple multipole program showed that the peak shift is dependent on interparticle gap size and binding position. The experimental peak shift distribution was also reproduced by simulation.

Single binding events of nanoparticle-labeled DNA strands were detected as stepwise peak shifts in localized surface plasmon resonance by single particle measurement. We confirmed the number of binding events by observing label particles by scanning electron microscopy. Our simulation based on a multiple multipole program showed that the peak shift is dependent on interparticle gap size and binding position. The experimental peak shift distribution was also reproduced by simulation.

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93 citations in Web of Science®
92 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Language:English
Date:2008
Deposited On:16 Dec 2008 13:07
Last Modified:05 Apr 2016 12:42
Publisher:American Chemical Society
ISSN:1530-6984
Publisher DOI:10.1021/nl802317d
PubMed ID:18767880

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