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Helicobacter pylori detected in pharyngeal and laryngeal pathologies in patients with proven gastric colonization


Fellmann, Jonas; Weisert, Jan U; Soltermann, Alex; Morand, Grégoire; Morra, Laura; Moch, Holger; Huber, Gerhard F; Probst, Rudolf (2014). Helicobacter pylori detected in pharyngeal and laryngeal pathologies in patients with proven gastric colonization. Head and Neck, 36(11):1562-1566.

Abstract

Background: Helicobacter pylori is known to cause gastric cancer. Presence and carcinogenicity in the upper aerodigestive system is doubtful. This study examined the prevalence of Helicobacter pylori and related factors in biopsies from the upper aerodigestive tract in patients with gastric colonization by Helicobacter pylori. Methods: In a case series study, 26 patients with histopathologically confirmed gastric colonization were identified. A polymerase chain reaction was performed on matched formalin-fixed and paraffin-embedded tissues of the stomach and the oral cavity, pharynx, or larynx. Results: Helicobacter pylori was found in 38% of the samples from the oral cavity, larynx and pharynx. An association with malignancies in these regions or possible risk factors such as age, smoking, or alcohol was not found. Conclusion: The upper aerodigestive system seems to be an additional reservoir in a significant percentage of patients presenting with Helicobacter pylori gastritis. Head Neck, 2013.

Background: Helicobacter pylori is known to cause gastric cancer. Presence and carcinogenicity in the upper aerodigestive system is doubtful. This study examined the prevalence of Helicobacter pylori and related factors in biopsies from the upper aerodigestive tract in patients with gastric colonization by Helicobacter pylori. Methods: In a case series study, 26 patients with histopathologically confirmed gastric colonization were identified. A polymerase chain reaction was performed on matched formalin-fixed and paraffin-embedded tissues of the stomach and the oral cavity, pharynx, or larynx. Results: Helicobacter pylori was found in 38% of the samples from the oral cavity, larynx and pharynx. An association with malignancies in these regions or possible risk factors such as age, smoking, or alcohol was not found. Conclusion: The upper aerodigestive system seems to be an additional reservoir in a significant percentage of patients presenting with Helicobacter pylori gastritis. Head Neck, 2013.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
04 Faculty of Medicine > University Hospital Zurich > Institute of Surgical Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:November 2014
Deposited On:23 Sep 2013 09:07
Last Modified:13 May 2016 10:29
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1043-3074
Publisher DOI:https://doi.org/10.1002/hed.23492
PubMed ID:23996235
Permanent URL: https://doi.org/10.5167/uzh-81216

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