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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-8140

Keiser, O; Gayet-Ageron, A; Rudin, C; Brinkhof, M W G; Gremlich, E; Wunder, D; Drack, G; Hirschel, B; de Tejada, B M (2008). Antiretroviral treatment during pregnancy. AIDS, 22(17):2323-2330.

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Abstract

OBJECTIVE: Virologic failure of HIV-positive patients is of special concern during pregnancy. We compared virologic failure and the frequency of treatment changes in pregnant and non-pregnant women of the Swiss HIV Cohort Study. METHODS: Using data on 372 pregnancies in 324 women we describe antiretroviral therapy during pregnancy. Pregnant women on HAART at conception (n = 131) were matched to 228 non-pregnant women (interindividual comparison) and to a time period of equal length before and after pregnancy (intraindividual comparison). Women starting HAART during pregnancy (n = 145) were compared with 578 non-pregnant women starting HAART. FINDINGS: The median age at conception was 31 years, 16% (n = 50) were infected through injecting drug use and the median CD4 cell count was 489 cells/microl. In the majority of pregnancies (n = 220, 59%), women had started ART before conception. When ART was started during pregnancy (n = 145, 39%), it was mainly during the second trimester (n = 100, 69%). Two thirds (n = 26) of 35 women starting in the third trimester were diagnosed with HIV during pregnancy. The risk of virologic failure tended to be lower in pregnant than in non-pregnant women [adjusted odds ratio 0.52 (95% confidence interval 0.25-1.09, P = 0.08)], but was similar in the intraindividual comparison (adjusted odds ratio 1.04, 95% confidence interval 0.48-2.28). Women starting HAART during pregnancy changed the treatment less often than non-pregnant women. CONCLUSION: Despite the physiological changes occurring during pregnancy, HIV infected pregnant women are not at higher risk of virologic failure.

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14 citations in Web of Science®
15 citations in Scopus®
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Additional indexing

Contributors:Swiss HIV Cohort Study (SHCS), Swiss Mother & Child HIV Cohort Study (MoCHiV)
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
DDC:610 Medicine & health
Language:English
Date:2008
Deposited On:22 Dec 2008 08:34
Last Modified:28 Nov 2013 00:15
Publisher:Lippincott Wiliams & Wilkins
ISSN:0269-9370
Publisher DOI:10.1097/QAD.0b013e3283189bf1
PubMed ID:18981771

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