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Soluble triggering receptor expressed on myeloid cells (sTREM)-1 in gingival crevicular fluid: Association with clinical and microbiological parameters


Belibasakis, Georgios N; Oztürk, Veli-Özgen; Emingil, Gulnur; Bostanci, Nagihan (2014). Soluble triggering receptor expressed on myeloid cells (sTREM)-1 in gingival crevicular fluid: Association with clinical and microbiological parameters. Journal of Periodontology, 85(1):204-210.

Abstract

Background: Soluble Triggering Receptor Expressed on Myeloid cells 1 (sTREM-1) belongs to the immunoglobulin superfamily, and is involved in the amplification of the inflammatory response to bacterial infection. This cross-sectional study aimed to investigate the levels of sTREM-1 in gingival crevicular fluid (GCF) of non-periodontitis subjects and patients with chronic periodontitis (CP) or generalized aggressive periodontitis (G-AgP), and their association with the levels of key periodontal pathogens in subgingival plaque. Methods: GCF and subgingival plaque samples were obtained from healthy sites of non-periodontitis individuals (n=20), and periodontitis sites of CP (n=22) and G-AgP (n=20) patients. sTREM-1 levels in GCF were measured by enzyme-linked immunosorbent assay. Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia and Aggregatibacter actinomycetemcomitans levels in subgingival plaque were analyzed by quantitative real-time polymerase chain reaction. Results: sTREM-1 levels in GCF were higher in CP and G-AgP than healthy sites, by 3.7-fold and 4.5-fold, respectively, with no significant differences between the two forms of periodontitis. Moreover, sTREM-1 levels in GCF positively correlated with site-specific clinical periodontal parameters, and levels of P. gingivalis, T. denticola, T. forsythia, but not A. actinomycetemcomitans, in subgingival plaque. Conclusions: The increased GCF levels of sTREM-1 at diseased sites and their positive correlation with clinical and microbiological parameters strengthen the association of this inflammatory marker with periodontitis.

Abstract

Background: Soluble Triggering Receptor Expressed on Myeloid cells 1 (sTREM-1) belongs to the immunoglobulin superfamily, and is involved in the amplification of the inflammatory response to bacterial infection. This cross-sectional study aimed to investigate the levels of sTREM-1 in gingival crevicular fluid (GCF) of non-periodontitis subjects and patients with chronic periodontitis (CP) or generalized aggressive periodontitis (G-AgP), and their association with the levels of key periodontal pathogens in subgingival plaque. Methods: GCF and subgingival plaque samples were obtained from healthy sites of non-periodontitis individuals (n=20), and periodontitis sites of CP (n=22) and G-AgP (n=20) patients. sTREM-1 levels in GCF were measured by enzyme-linked immunosorbent assay. Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia and Aggregatibacter actinomycetemcomitans levels in subgingival plaque were analyzed by quantitative real-time polymerase chain reaction. Results: sTREM-1 levels in GCF were higher in CP and G-AgP than healthy sites, by 3.7-fold and 4.5-fold, respectively, with no significant differences between the two forms of periodontitis. Moreover, sTREM-1 levels in GCF positively correlated with site-specific clinical periodontal parameters, and levels of P. gingivalis, T. denticola, T. forsythia, but not A. actinomycetemcomitans, in subgingival plaque. Conclusions: The increased GCF levels of sTREM-1 at diseased sites and their positive correlation with clinical and microbiological parameters strengthen the association of this inflammatory marker with periodontitis.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Institute of Oral Biology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2014
Deposited On:18 Oct 2013 13:00
Last Modified:05 Apr 2016 17:03
Publisher:American Academy of Periodontology
ISSN:0022-3492
Publisher DOI:https://doi.org/10.1902/jop.2013.130144
PubMed ID:23659423

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