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Conformational Analysis of the Cyclic Pentadepsipeptide Cyclo(Tro-Aib-Aib-Aib-Aib) in the Solid State and in Solution


Koch, Kristian N; Hopp, Gudrun; Linden, Anthony; Moehle, Kerstin; Heimgartner, Heinz (2001). Conformational Analysis of the Cyclic Pentadepsipeptide Cyclo(Tro-Aib-Aib-Aib-Aib) in the Solid State and in Solution. Helvetica Chimica Acta, 84(2):502-512.

Abstract

The cyclic 16-membered pentadepsipeptide cyclo(Tro-Aib-Aib-Aib-Aib) (1) was crystallized from MeOH/AcOEt/CH2Cl2, and its structure was established by X-ray crystallography (Fig. 1). There are two symmetry-independent molecules with different conformations in the asymmetric unit. Two intramolecular H-bonds stabilize two beta-turns in each molecule. On the other hand, two of the four Aib residues are forced to assume a nonfavorable nonhelical conformation in each of the symmetry-independent molecules (Table 1). The conformational study in CDCl3 solution by NMR spectroscopy and molecular dynamics (MD) simulations indicate that the averaged structure (Fig. 3) is almost the same as in the solid state.

The cyclic 16-membered pentadepsipeptide cyclo(Tro-Aib-Aib-Aib-Aib) (1) was crystallized from MeOH/AcOEt/CH2Cl2, and its structure was established by X-ray crystallography (Fig. 1). There are two symmetry-independent molecules with different conformations in the asymmetric unit. Two intramolecular H-bonds stabilize two beta-turns in each molecule. On the other hand, two of the four Aib residues are forced to assume a nonfavorable nonhelical conformation in each of the symmetry-independent molecules (Table 1). The conformational study in CDCl3 solution by NMR spectroscopy and molecular dynamics (MD) simulations indicate that the averaged structure (Fig. 3) is almost the same as in the solid state.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2001
Deposited On:23 Oct 2013 06:35
Last Modified:05 Apr 2016 17:03
Publisher:Wiley-Blackwell
ISSN:0018-019X
Funders:Swiss National Science Foundation, F. Hoffmann-La Roche AG, Basel
Publisher DOI:https://doi.org/10.1002/1522-2675(20010228)84:2<502::AID-HLCA502>3.0.CO;2-#
Permanent URL: https://doi.org/10.5167/uzh-82092

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