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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-8445

Gloddek, B; Bodmer, D; Brors, D; Keithley, E M; Ryan, A F (2002). Induction of MHC class II antigens on cells of the inner ear. Audiology & Neurotology, 7(6):317-323.

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Growing evidence supports the concept that immune reactions occur in the cochlea, where they can function either in protection or as a source of inflammation. Since immunity is generally initiated by antigen presentation of foreign substances to T cells, antigen-presenting cells expressing major histocompatibility complex (MHC) class II molecules are required. Under resting conditions, cochlear cells usually express no MHC class II. However, we show that exposure to -interferon in vitro induces an increase in MHC class II expression in neonatal cochlear cells of mice. In addition, MHC class II immunoreactivity was observed in the inner ear of adult mice after induction of sterile labyrinthitis in vivo. It is concluded that the induction of MHC class II molecules by inflammation may render cochlear cells competent to initiate and participate in immune reactions and may therefore contribute to both immunoprotective and immunopathological responses of the inner ear.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
DDC:610 Medicine & health
Deposited On:26 Mar 2009 13:21
Last Modified:01 Dec 2013 09:48
Publisher:American Chemical Society
Publisher DOI:10.1159/000066158
PubMed ID:12463193
Citations:Web of Science®. Times Cited: 4
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Scopus®. Citation Count: 5

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