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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-8448

Bodmer, D; Brors, D; Pak, K; Keithley, E M; Mullen, L; Ryan, A F; Gloddek, B (2002). Inflammatory signals increase Fas ligand expression by inner ear cells. Journal of Neuroimmunology, 129(1-2):10-17.



There is considerable evidence that hearing and vestibular function can be influenced by immune processes. The inner ear has evolved mechanisms, such as the blood-labyrinthine barrier that limit immune responses and autoimmune processes to reduce the potential for damage to cochlear cells. Recently, expression of Fas ligand (FasL) in some non-lymphoid tissue, as in the anterior chamber of the eye, has been hypothesized to play a role in protection of sensitive organs from activated T-cells. We show that under resting conditions, cochlear cells express little or no FasL. However, after exposure to interferon-gamma in vitro, FasL is induced in many neonatal cochlear cells. In addition, we show that FasL is upregulated in adult cochlear cells after induction of a sterile labyrinthitis in vivo. The induction of FasL by inflammation may serve to limit cochlear immune responses, and to protect sensorineural tissue from immune and autoimmune damage.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
DDC:610 Medicine & health
Deposited On:26 Mar 2009 13:07
Last Modified:13 Dec 2013 13:23
Publisher DOI:10.1016/S0165-5728(02)00143-1
PubMed ID:12161015
Citations:Web of Science®. Times Cited: 13
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Scopus®. Citation Count: 13

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