Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-8448
Bodmer, D; Brors, D; Pak, K; Keithley, E M; Mullen, L; Ryan, A F; Gloddek, B (2002). Inflammatory signals increase Fas ligand expression by inner ear cells. Journal of Neuroimmunology, 129(1-2):10-17.
There is considerable evidence that hearing and vestibular function can be influenced by immune processes. The inner ear has evolved mechanisms, such as the blood-labyrinthine barrier that limit immune responses and autoimmune processes to reduce the potential for damage to cochlear cells. Recently, expression of Fas ligand (FasL) in some non-lymphoid tissue, as in the anterior chamber of the eye, has been hypothesized to play a role in protection of sensitive organs from activated T-cells. We show that under resting conditions, cochlear cells express little or no FasL. However, after exposure to interferon-gamma in vitro, FasL is induced in many neonatal cochlear cells. In addition, we show that FasL is upregulated in adult cochlear cells after induction of a sterile labyrinthitis in vivo. The induction of FasL by inflammation may serve to limit cochlear immune responses, and to protect sensorineural tissue from immune and autoimmune damage.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology|
|DDC:||610 Medicine & health|
|Deposited On:||26 Mar 2009 14:07|
|Last Modified:||27 Nov 2013 18:21|
|Citations:||Web of Science®. Times cited: 13|
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