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DMSO-Mediated ligand dissociation: renaissance for biological activity of n-heterocyclic-[Ru(η(6) -arene)Cl2 ] Drug Candidates


Patra, Malay; Joshi, Tanmaya; Pierroz, Vanessa; Ingram, Katrin; Kaiser, Marcel; Ferrari, Stefano; Spingler, Bernhard; Keiser, Jennifer; Gasser, Gilles (2013). DMSO-Mediated ligand dissociation: renaissance for biological activity of n-heterocyclic-[Ru(η(6) -arene)Cl2 ] Drug Candidates. Chemistry - A European Journal:14768-14772.

Abstract

Slipped under the radar? (1) H NMR spectroscopic examination revealed that [Ru(η(6) -arene)Cl2 (L)] (L=N-heterocyclic ligands) complexes readily undergo ligand exchange reaction in DMSO, a popular medium for preparing stock solutions for biological screening. It is therefore highly important for researchers to study stability in DMSO before reporting on the biological activity of such type of complexes.

Slipped under the radar? (1) H NMR spectroscopic examination revealed that [Ru(η(6) -arene)Cl2 (L)] (L=N-heterocyclic ligands) complexes readily undergo ligand exchange reaction in DMSO, a popular medium for preparing stock solutions for biological screening. It is therefore highly important for researchers to study stability in DMSO before reporting on the biological activity of such type of complexes.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Molecular Cancer Research
07 Faculty of Science > Institute of Molecular Cancer Research

07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:570 Life sciences; biology
540 Chemistry
Language:English
Date:2013
Deposited On:14 Nov 2013 16:05
Last Modified:05 Apr 2016 17:08
Publisher:Wiley-VCH Verlag Berlin
ISSN:0947-6539
Publisher DOI:https://doi.org/10.1002/chem.201303341
PubMed ID:24123460
Permanent URL: https://doi.org/10.5167/uzh-84867

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