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Viral and cellular components of AAV2 replication compartments


Vogel, Rebecca; Seyffert, Michael; de Andrade Pereira, Bruna; Fraefel, C (2013). Viral and cellular components of AAV2 replication compartments. Open Virology Journal, 2013(7):98-120.

Abstract

Adeno-associated virus 2 (AAV2) is a helpervirus-dependent parvovirus with a bi-phasic life cycle comprising latency in absence and lytic replication in presence of a helpervirus, such as adenovirus (Ad) or herpes simplex virus type 1 (HSV-1). Helpervirus-supported AAV2 replication takes place in replication compartments (RCs) in the cell nucleus where virus DNA replication and transcription occur. RCs consist of a defined set of helper virus-, AAV2-, and cellular proteins. Here we compare the profile of cellular proteins recruited into AAV2 RCs or identified in Rep78-associated complexes when either Ad or HSV-1 is the helpervirus, and we discuss the potential roles of some of these proteins in AAV2 and helpervirus infection. Keywords: AAV2, HSV-1, adenovirus, replication compartments.

Adeno-associated virus 2 (AAV2) is a helpervirus-dependent parvovirus with a bi-phasic life cycle comprising latency in absence and lytic replication in presence of a helpervirus, such as adenovirus (Ad) or herpes simplex virus type 1 (HSV-1). Helpervirus-supported AAV2 replication takes place in replication compartments (RCs) in the cell nucleus where virus DNA replication and transcription occur. RCs consist of a defined set of helper virus-, AAV2-, and cellular proteins. Here we compare the profile of cellular proteins recruited into AAV2 RCs or identified in Rep78-associated complexes when either Ad or HSV-1 is the helpervirus, and we discuss the potential roles of some of these proteins in AAV2 and helpervirus infection. Keywords: AAV2, HSV-1, adenovirus, replication compartments.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Virology
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:July 2013
Deposited On:19 Nov 2013 16:51
Last Modified:05 Apr 2016 17:10
Publisher:Bentham Open
ISSN:1874-3579
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.2174/1874357901307010098
Permanent URL: https://doi.org/10.5167/uzh-85194

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