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Mossi, R; Hübscher, U (1998). Clamping down on clamps and clamp loaders--the eukaryotic replication factor C. FEBS Journal, 254(2):209-216.

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Abstract

DNA transactions such as DNA replication and DNA repair require the concerted action of many enzymes, together with other proteins and non-protein cofactors. Among them three main accessory proteins, replication factor C (RF-C), proliferating-cell nuclear antigen (PCNA) and replication protein A (RP-A), are essential for accurate and processive DNA synthesis by DNA polymerases. RF-C is a complex consisting of five polypeptides with distinct functions. RF-C can bind to a template-primer junction and, in the presence of ATP, load the PCNA clamp onto DNA, thereby recruiting DNA polymerases to the site of DNA synthesis. RF-C not only acts as a clamp loader in DNA replication and DNA repair, but there is some evidence that it could be involved in several other processes such as transcription, S-phase checkpoint regulation, apoptosis, differentiation and telomere-length regulation.

Citations

128 citations in Web of Science®
129 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Biochemistry and Molecular Biology
DDC:570 Life sciences; biology
Language:English
Date:1 June 1998
Deposited On:11 Feb 2008 12:18
Last Modified:04 Apr 2012 12:11
Publisher:Wiley-Blackwell
ISSN:0014-2956
Publisher DOI:10.1046/j.1432-1327.1998.254209.x
PubMed ID:9660172

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