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Serum bilirubin is associated with lung function in a Swiss general population sample


Curjuric, Ivan; Imboden, Medea; Adam, Martin; Bettschart, Robert W; Gerbase, Margaret W; Künzli, Nino; Rochat, Thierry; Rohrer, Lucia; Rothe, Thomas B; Schwartz, Joel; Stolz, Daiana; Tschopp, Jean-Marie; von Eckardstein, Arnold; Kronenberg, Florian; Probst-Hensch, Nicole M (2014). Serum bilirubin is associated with lung function in a Swiss general population sample. European Respiratory Journal, 43(5):1278-1288.

Abstract

Bilirubin is a strong antioxidant. Increased serum levels were associated with respiratory disease and mortality risk. We studied the association of bilirubin with lung function in the SAPALDIA cohort.Associations between natural logarithmized bilirubin and forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC, and mean forced expiratory flow between 25%-75% of FVC (FEF25-75) were tested using multiple linear regression in the whole study population (n=4195) and strata of ever smoking and high body mass index (BMI, defined by the highest distribution quartile). Associations were retested with single nucleotide polymorphism rs6742078, a genetic determinant of bilirubin.High bilirubin levels were significantly associated with higher FEV1/FVC and FEF25-75 overall. Upon stratification, significant associations persisted in ever smokers, amounting to 1.1 percent (95%-confidence interval 0.1 to 2.2) increase in FEV1/FVC, and 116.2 mL·sec(-1) (-15.9 to 248.4) in FEF25-75 per interquartile range of bilirubin exposure in smokers with high BMI. Associations were positive but non -significant in never smokers with high BMI. Similarly, rs6742078 genotype TT was associated with increased FEV1/FVC and FEF25-75.Our results suggest a possible protective role of bilirubin on lung tissue, which could be important for prevention and therapy.

Abstract

Bilirubin is a strong antioxidant. Increased serum levels were associated with respiratory disease and mortality risk. We studied the association of bilirubin with lung function in the SAPALDIA cohort.Associations between natural logarithmized bilirubin and forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC, and mean forced expiratory flow between 25%-75% of FVC (FEF25-75) were tested using multiple linear regression in the whole study population (n=4195) and strata of ever smoking and high body mass index (BMI, defined by the highest distribution quartile). Associations were retested with single nucleotide polymorphism rs6742078, a genetic determinant of bilirubin.High bilirubin levels were significantly associated with higher FEV1/FVC and FEF25-75 overall. Upon stratification, significant associations persisted in ever smokers, amounting to 1.1 percent (95%-confidence interval 0.1 to 2.2) increase in FEV1/FVC, and 116.2 mL·sec(-1) (-15.9 to 248.4) in FEF25-75 per interquartile range of bilirubin exposure in smokers with high BMI. Associations were positive but non -significant in never smokers with high BMI. Similarly, rs6742078 genotype TT was associated with increased FEV1/FVC and FEF25-75.Our results suggest a possible protective role of bilirubin on lung tissue, which could be important for prevention and therapy.

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5 citations in Web of Science®
4 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Clinical Chemistry
Dewey Decimal Classification:610 Medicine & health
540 Chemistry
Language:English
Date:May 2014
Deposited On:13 Dec 2013 14:19
Last Modified:05 Apr 2016 17:14
Publisher:European Respiratory Society
ISSN:0903-1936
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1183/09031936.00055813
PubMed ID:24177000

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