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Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment


Welle, M M; Rohrer Bley, C; Howard, J; Rüfenacht, S (2008). Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment. Veterinary Dermatology, 19(6):321-339.

Abstract

Mast cells (MCs) are well known for their neoplastic transformation in solitary and multiple cutaneous mast cell tumours (MCTs), as well as visceral and systemic mastocytosis. Dogs have an unique risk of developing cutaneous MCTs, and they account for 7% to 21% of all canine skin tumours. The aetiology of canine MCTs is unknown but is probably multi-factorial. This article reviews uptodate knowledge on the pathogenesis, the clinical presentation, the clinical prognostic factors, the diagnostic workup including clinical staging, cytological findings, histological findings and the various grading systems which have been evaluated based on morphology, the assessment of proliferation markers and other factors such as vessel density. Furthermore detailed information about current treatment protocols for canine cutaneous MCTs are provided.

Abstract

Mast cells (MCs) are well known for their neoplastic transformation in solitary and multiple cutaneous mast cell tumours (MCTs), as well as visceral and systemic mastocytosis. Dogs have an unique risk of developing cutaneous MCTs, and they account for 7% to 21% of all canine skin tumours. The aetiology of canine MCTs is unknown but is probably multi-factorial. This article reviews uptodate knowledge on the pathogenesis, the clinical presentation, the clinical prognostic factors, the diagnostic workup including clinical staging, cytological findings, histological findings and the various grading systems which have been evaluated based on morphology, the assessment of proliferation markers and other factors such as vessel density. Furthermore detailed information about current treatment protocols for canine cutaneous MCTs are provided.

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58 citations in Web of Science®
64 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:13 October 2008
Deposited On:17 Dec 2008 14:16
Last Modified:05 Apr 2016 12:44
Publisher:Wiley-Blackwell
ISSN:0959-4493
Additional Information:The definitive version is available at www.blackwell-synergy.com
Publisher DOI:https://doi.org/10.1111/j.1365-3164.2008.00694.x
PubMed ID:18980632

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