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Heat-induced dry tailoring of porosity in polymer scaffolds


Hild, Nora; Abaecherli, Matteo L; Mohn, Dirk; Stark, Wendelin J (2013). Heat-induced dry tailoring of porosity in polymer scaffolds. Macromolecular Materials and Engineering, 298(11):1143-1148.

Abstract

The present study evaluates the effect of heat treatment on electrospun poly(lactide-co-glycolide) fibrous membranes. Both a temperature (75–150 °C) and a treatment time range (5–40 min) are tested. The effect on the fibrous structure is investigated in terms of morphology, showing that with increasing temperature or longer treatment time the fusion of fibres progresses continuously. Additionally, the tensile properties of the various scaffolds deliver results on the effect of increasing fibre-to-fibre linkages. Both modulus and yield increase within the heat treatment procedures. The elevated stiffness of the membranes accompanies a loss in porosity. These findings deliver insights into the tailoring of membranes that might be used in the fabrication of customised scaffolds intended for cell culture in tissue engineering.

Abstract

The present study evaluates the effect of heat treatment on electrospun poly(lactide-co-glycolide) fibrous membranes. Both a temperature (75–150 °C) and a treatment time range (5–40 min) are tested. The effect on the fibrous structure is investigated in terms of morphology, showing that with increasing temperature or longer treatment time the fusion of fibres progresses continuously. Additionally, the tensile properties of the various scaffolds deliver results on the effect of increasing fibre-to-fibre linkages. Both modulus and yield increase within the heat treatment procedures. The elevated stiffness of the membranes accompanies a loss in porosity. These findings deliver insights into the tailoring of membranes that might be used in the fabrication of customised scaffolds intended for cell culture in tissue engineering.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Clinic for Preventive Dentistry, Periodontology and Cariology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2013
Deposited On:18 Dec 2013 09:45
Last Modified:05 Apr 2016 17:16
Publisher:Wiley
ISSN:1439-2054
Publisher DOI:https://doi.org/10.1002/mame.201200327

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