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Nogo-A represses anatomical and synaptic plasticity in the central nervous system


Kempf, Anissa; Schwab, Martin E (2013). Nogo-A represses anatomical and synaptic plasticity in the central nervous system. Physiology, 28(3):151-163.

Abstract

Nogo-A was initially discovered as a myelin-associated growth inhibitory protein limiting axonal regeneration after central nervous system (CNS) injury. This review summarizes current knowledge on how myelin and neuronal Nogo-A and its receptors exert physiological functions ranging from the regulation of growth suppression to synaptic plasticity in the developing and adult intact CNS.

Abstract

Nogo-A was initially discovered as a myelin-associated growth inhibitory protein limiting axonal regeneration after central nervous system (CNS) injury. This review summarizes current knowledge on how myelin and neuronal Nogo-A and its receptors exert physiological functions ranging from the regulation of growth suppression to synaptic plasticity in the developing and adult intact CNS.

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22 citations in Web of Science®
22 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Brain Research Institute
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2013
Deposited On:18 Dec 2013 13:51
Last Modified:05 Apr 2016 17:17
Publisher:American Physiological Society
ISSN:1548-9221
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1152/physiol.00052.2012
PubMed ID:23636261

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