Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-872
Ahmadi, S A; Muth-Selbach, U; Lauterbach, A; Lipfert, P; Neuhuber, W L; Zeilhofer, H U (2003). Facilitation of spinal NMDA receptor currents by spillover of synaptically released glycine. Science, 300(5628):2094-2097.
In the mammalian CNS, N-methyl-D-aspartate (NMDA) receptors serve prominent roles in many physiological and pathophysiological processes including pain transmission. For full activation, NMDA receptors require the binding of glycine. It is not known whether the brain uses changes in extracellular glycine to modulate synaptic NMDA responses. Here, we show that synaptically released glycine facilitates NMDA receptor currents in the superficial dorsal horn, an area critically involved in pain processing. During high presynaptic activity, glycine released from inhibitory interneurons escapes the synaptic cleft and reaches nearby NMDA receptors by so-called spillover. In vivo, this process may contribute to the development of inflammatory hyperalgesia.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Pharmacology and Toxicology|
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Date:||27 June 2003|
|Deposited On:||11 Feb 2008 13:18|
|Last Modified:||27 Nov 2013 17:22|
|Publisher:||American Association for the Advancement of Science (AAAS)|
|Additional Information:||Authors have permission by AAAS to show PDF|
|Citations:||Web of Science®. Times cited: 67|
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