UZH-Logo

Maintenance Infos

Facilitation of spinal NMDA receptor currents by spillover of synaptically released glycine


Ahmadi, S A; Muth-Selbach, U; Lauterbach, A; Lipfert, P; Neuhuber, W L; Zeilhofer, H U (2003). Facilitation of spinal NMDA receptor currents by spillover of synaptically released glycine. Science, 300(5628):2094-2097.

Abstract

In the mammalian CNS, N-methyl-D-aspartate (NMDA) receptors serve prominent roles in many physiological and pathophysiological processes including pain transmission. For full activation, NMDA receptors require the binding of glycine. It is not known whether the brain uses changes in extracellular glycine to modulate synaptic NMDA responses. Here, we show that synaptically released glycine facilitates NMDA receptor currents in the superficial dorsal horn, an area critically involved in pain processing. During high presynaptic activity, glycine released from inhibitory interneurons escapes the synaptic cleft and reaches nearby NMDA receptors by so-called spillover. In vivo, this process may contribute to the development of inflammatory hyperalgesia.

Abstract

In the mammalian CNS, N-methyl-D-aspartate (NMDA) receptors serve prominent roles in many physiological and pathophysiological processes including pain transmission. For full activation, NMDA receptors require the binding of glycine. It is not known whether the brain uses changes in extracellular glycine to modulate synaptic NMDA responses. Here, we show that synaptically released glycine facilitates NMDA receptor currents in the superficial dorsal horn, an area critically involved in pain processing. During high presynaptic activity, glycine released from inhibitory interneurons escapes the synaptic cleft and reaches nearby NMDA receptors by so-called spillover. In vivo, this process may contribute to the development of inflammatory hyperalgesia.

Citations

83 citations in Web of Science®
91 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

141 downloads since deposited on 11 Feb 2008
57 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:27 June 2003
Deposited On:11 Feb 2008 12:18
Last Modified:05 Apr 2016 12:16
Publisher:American Association for the Advancement of Science (AAAS)
ISSN:0036-8075
Additional Information:Authors have permission by AAAS to show PDF
Publisher DOI:https://doi.org/10.1126/science.1083970
PubMed ID:12829784

Download

[img]
Preview
Filetype: PDF
Size: 710kB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations