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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-872

Ahmadi, S A; Muth-Selbach, U; Lauterbach, A; Lipfert, P; Neuhuber, W L; Zeilhofer, H U (2003). Facilitation of spinal NMDA receptor currents by spillover of synaptically released glycine. Science, 300(5628):2094-2097.

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Abstract

In the mammalian CNS, N-methyl-D-aspartate (NMDA) receptors serve prominent roles in many physiological and pathophysiological processes including pain transmission. For full activation, NMDA receptors require the binding of glycine. It is not known whether the brain uses changes in extracellular glycine to modulate synaptic NMDA responses. Here, we show that synaptically released glycine facilitates NMDA receptor currents in the superficial dorsal horn, an area critically involved in pain processing. During high presynaptic activity, glycine released from inhibitory interneurons escapes the synaptic cleft and reaches nearby NMDA receptors by so-called spillover. In vivo, this process may contribute to the development of inflammatory hyperalgesia.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:27 June 2003
Deposited On:11 Feb 2008 12:18
Last Modified:27 Nov 2013 16:22
Publisher:American Association for the Advancement of Science (AAAS)
ISSN:0036-8075
Additional Information:Authors have permission by AAAS to show PDF
Publisher DOI:10.1126/science.1083970
PubMed ID:12829784
Citations:Web of Science®. Times Cited: 71
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Scopus®. Citation Count: 77

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