Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-8733
Perger, L; Rentsch, K M; Kullak-Ublick, G A; Verotta, D; Fattinger, K (2009). Oral heroin in opioid-dependent patients: Pharmacokinetic comparison of immediate and extended release tablets. European Journal of Pharmaceutical Sciences, 36(4-5):421-432.
|Accepted Version (Creative Commons: Attribution 3.0)|
In diacetylmorphine prescription programs for heavily dependent addicts, diacetylmorphine is usually administered intravenously, but this may not be possible due to venosclerosis or when heroin abuse had occurred via non-intravenous routes. Since up to 25% of patients administer diacetylmorphine orally, we characterised morphine absorption after single oral doses of immediate and extended release diacetylmorphine in 8 opioid addicts. Plasma concentrations were determined by liquid chromatography-mass spectrometry. Non-compartmental methods and deconvolution were applied for data analysis. Mean (+/-S.D.) immediate and extended release doses were 719+/-297 and 956+/-404mg, with high absolute morphine bioavailabilities of 56-61%, respectively. Immediate release diacetylmorphine caused rapid morphine absorption, peaking at 10-15min. Morphine absorption was considerably slower and more sustained for extended release diacetylmorphine, with only approximately 30% of maximal immediate release absorption being reached after 10min and maintained for 3-4h, with no relevant food interaction. The relative extended to immediate release bioavailability was calculated to be 86% by non-compartmental analysis and 93% by deconvolution analysis. Thus, immediate and extended release diacetylmorphine produce the intended morphine exposures. Both are suitable for substitution treatments. Similar doses can be applied if used in combination or sequentially.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology|
04 Faculty of Medicine > University Hospital Zurich > Institute of Clinical Chemistry
|DDC:||610 Medicine & health|
|Date:||02 March 2009|
|Deposited On:||12 Jan 2009 14:53|
|Last Modified:||23 Nov 2012 17:29|
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