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Molecular biology of high grade gliomas: what should the clinician know?


Hofer, Silvia; Rushing, Elisabeth; Preusser, Matthias; Marosi, Christine (2014). Molecular biology of high grade gliomas: what should the clinician know? Chinese Journal of Cancer, 33(1):4-7.

Abstract

The current World Health Organization (WHO) classification system of primary brain tumors is solely based on morphologic criteria. However,there is accumulating evidence that tumors with similar histology have distinct molecular signatures that significantly impact treatment response and survival. Recent practice-changing clinical trials have defined a role for routine assessment of MGMT promoter methylation in glioblastoma patients,especially in the elderly,and 1p and 19q co-deletions in patients with anaplastic glial tumors. Recently discovered molecular alterations including mutations in IDH-1/2,EGFR,and BRAF also have the potential to become targets for future drug development. This article aims to summarize current knowledge on the molecular biology of high grade gliomas relevant to daily practice.

The current World Health Organization (WHO) classification system of primary brain tumors is solely based on morphologic criteria. However,there is accumulating evidence that tumors with similar histology have distinct molecular signatures that significantly impact treatment response and survival. Recent practice-changing clinical trials have defined a role for routine assessment of MGMT promoter methylation in glioblastoma patients,especially in the elderly,and 1p and 19q co-deletions in patients with anaplastic glial tumors. Recently discovered molecular alterations including mutations in IDH-1/2,EGFR,and BRAF also have the potential to become targets for future drug development. This article aims to summarize current knowledge on the molecular biology of high grade gliomas relevant to daily practice.

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7 citations in Web of Science®
10 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2014
Deposited On:03 Jan 2014 10:21
Last Modified:05 Apr 2016 17:20
Publisher:Zhongshan yi ke da xue Fu shu zhong liu yi yuan
ISSN:1000-467X
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.5732/cjc.013.10218
PubMed ID:24325789
Permanent URL: https://doi.org/10.5167/uzh-87645

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