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Synthesis, crystal structures, cytotoxicity and qualitative structure–activity relationship (QSAR) of cis-bis{5-[(E)-2-(aryl)-1-diazenyl]quinolinolato}di-n-butyltin(IV) complexes, nBu2Sn(L)2


Basu Baul, T S; Mizar, A; Chandra, A K; Song, X; Eng, G; Jurasko, R; Holcapek, M; De Vos, D; Linden, A (2008). Synthesis, crystal structures, cytotoxicity and qualitative structure–activity relationship (QSAR) of cis-bis{5-[(E)-2-(aryl)-1-diazenyl]quinolinolato}di-n-butyltin(IV) complexes, nBu2Sn(L)2. Journal of Inorganic Biochemistry, 102(9):1719-1730.

Abstract

A series of cis-bis{5-[(E)-2-(aryl)-1-diazenyl]quinolinolato}di-n-butyltin(IV) complexes has been synthesized and characterized by 1H-, 13C-, 119Sn NMR, ESI–MS (electrospray ionization mass spectrometry), IR
and 119mSn Mössbauer spectroscopic techniques in combination with elemental analyses. The structures
of four di-n-butyltin(IV) complexes, viz., nBu2Sn(L3)2 (3), nBu2Sn(L4)2 (4), nBu2Sn(L5)2 (5) and nBu2Sn(L7)2 0.5C6H6 (7) (LH = 5-[(E)-2-(aryl)-1-diazenyl)quinolin-8-ol) were determined by single crystal X-ray diffraction. In general, the complexes were found to adopt a distorted cis-octahedral arrangement around the tin atom. These complexes retain their solid-state structure in non-coordinating solvent as evidenced by 119Sn and 13C NMR spectroscopic results. The in vitro cytotoxicity of di-n-butyltin(IV) complexes (3–8) is reported against seven well characterized human tumour cell lines. The basicity
of the two quinolinolato donor N and O atoms of the ligands are discussed in relation to the cytotoxicity data.

A series of cis-bis{5-[(E)-2-(aryl)-1-diazenyl]quinolinolato}di-n-butyltin(IV) complexes has been synthesized and characterized by 1H-, 13C-, 119Sn NMR, ESI–MS (electrospray ionization mass spectrometry), IR
and 119mSn Mössbauer spectroscopic techniques in combination with elemental analyses. The structures
of four di-n-butyltin(IV) complexes, viz., nBu2Sn(L3)2 (3), nBu2Sn(L4)2 (4), nBu2Sn(L5)2 (5) and nBu2Sn(L7)2 0.5C6H6 (7) (LH = 5-[(E)-2-(aryl)-1-diazenyl)quinolin-8-ol) were determined by single crystal X-ray diffraction. In general, the complexes were found to adopt a distorted cis-octahedral arrangement around the tin atom. These complexes retain their solid-state structure in non-coordinating solvent as evidenced by 119Sn and 13C NMR spectroscopic results. The in vitro cytotoxicity of di-n-butyltin(IV) complexes (3–8) is reported against seven well characterized human tumour cell lines. The basicity
of the two quinolinolato donor N and O atoms of the ligands are discussed in relation to the cytotoxicity data.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2008
Deposited On:16 Jan 2009 13:02
Last Modified:05 Apr 2016 12:44
Publisher:Elsevier
ISSN:0162-0134
Funders:Department of Science and Technology,New Delhi, India (Grant Nos. SR/S1/IC-03/2005, TSBB; SR/S1/PC-13/2005, AKC), University Grants Commission, New Delhi,India through SAP-DSA, Phase-III, Ministry of Education,Youth and Sports of the Czech Republic (Grant project NoMSM0021627502, National Institutes of HealthMinority Biomedical Research Support Program, USA (Grant No.GM08005, GE)
Publisher DOI:https://doi.org/10.1016/j.jinorgbio.2008.05.001
Permanent URL: https://doi.org/10.5167/uzh-8787

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