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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-8831

Riond, B; Meli, M L; Braun, U; Deplazes, P; Joerger, K; Thoma, R; Lutz, H; Hofmann-Lehmann, R (2008). Concurrent infections with vector-borne pathogens associated with fatal anaemia in cattle: haematology and blood chemistry. Comparative Clinical Pathology, (17):171-177.

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Abstract

An outbreak of a fatal haemolytic anaemia in a dairy herd of cattle in Switzerland was shown to be associated with infections with five vector-borne pathogens, namely Anaplasma marginale, A. phagocytophilum, Babesia bigemina, a Theileria spp belonging to the buffeli/sergenti/orientalis complex and haemotrophic Mycoplasma spp. The latter three had not been documented before this outbreak in Switzerland. To characterise the haematological and blood chemical changes in these unique cows, packed cell volume was determined in all 286 blood samples, blood smears, and complete haematology were performed from 285 and 173 blood samples, respectively, and biochemical parameters were assayed in 105 serum samples. Regenerative anaemia was the key sign of illness. Red blood cells of anaemic cattle were hypochromic and macrocytic. Anaemic animals had reduced platelet cell counts and increased total white cell counts. In addition, increased serum bilirubin, blood aspartate aminotransferase, gamma glutamyltransferase, glutamic dehydrogenase and blood urea nitrogen and decreased magnesium, calcium and albumin levels were found in anaemic cattle when compared to animals with normal packed cell volume. Most changes could not be attributed to a single infection. A. marginale seemed to be important in causing the outbreak, but co-infections may have aggravated the disease development and clinical signs. Thus, when encountering cattle with haemolytic anaemia, all of the mentioned pathogens should be included as differential diagnosis.

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals > Clinical Laboratory
05 Vetsuisse Faculty > Institute of Parasitology
04 Faculty of Medicine > Institute of Parasitology

05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals > Clinic for Ruminants
DDC:570 Life sciences; biology
610 Medicine & health
600 Technology
630 Agriculture
Language:English
Date:2008
Deposited On:23 Dec 2008 11:20
Last Modified:29 Nov 2012 21:59
Publisher:Springer
ISSN:1618-5641
Additional Information:"The original publication is available at www.springerlink.com
Publisher DOI:10.1007/s00580-007-0713-z
Citations:Google Scholar™
Scopus®. Citation Count: 1

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