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The grey mouse lemur: A non-human primate model for ageing studies


Languille, S; Blanc, S; Blin, O; Canale, C I; Dal-Pan, A; Devau, G; Dhenain, M; Dorieux, O; Epelbaum, J; Gomez, D; Hardy, I; Henry, P-Y; Irving, E A; Marchal, J; Mestre-Francés, N; Perret, M; Picq, J-L; Pifferi, F; Rahman, A; Schenker, E; Terrien, J; Théry, M; Verdier, J-M; Aujard, F (2012). The grey mouse lemur: A non-human primate model for ageing studies. Ageing Research Reviews, 11(1):150-162.

Abstract

The use of non-human primate models is required to understand the ageing process and evaluate new therapies against age-associated pathologies. The present article summarizes all the contributions of the grey mouse lemur Microcebus murinus, a small nocturnal prosimian primate, to the understanding of the mechanisms of ageing. Results from studies of both healthy and pathological ageing research on the grey mouse lemur demonstrated that this animal is a unique model to study age-dependent changes in endocrine systems, biological rhythms, thermoregulation, sensorial, cerebral and cognitive functions.

Abstract

The use of non-human primate models is required to understand the ageing process and evaluate new therapies against age-associated pathologies. The present article summarizes all the contributions of the grey mouse lemur Microcebus murinus, a small nocturnal prosimian primate, to the understanding of the mechanisms of ageing. Results from studies of both healthy and pathological ageing research on the grey mouse lemur demonstrated that this animal is a unique model to study age-dependent changes in endocrine systems, biological rhythms, thermoregulation, sensorial, cerebral and cognitive functions.

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40 citations in Web of Science®
44 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Institute of Evolutionary Biology and Environmental Studies
Dewey Decimal Classification:570 Life sciences; biology
590 Animals (Zoology)
Language:English
Date:2012
Deposited On:28 Feb 2014 08:06
Last Modified:05 Apr 2016 17:23
Publisher:Elsevier
ISSN:1568-1637
Publisher DOI:https://doi.org/10.1016/j.arr.2011.07.001

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