Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-8856
Trachsler, J; Gaspert, A; Previsdomini, M; Wüthrich, R P; Fehr, T (2008). Massive uric acid nephrolithiasis with progressive renal failure due to spontaneous tumour lysis syndrome. NDT Plus, 5(1):307-309.
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Tumour lysis syndrome (TLS) is a constellation of metabolic complications due to the rapid destruction of malignant cells, causing renal, cardiac or cerebral dysfunction. Electrolyte abnormalities include hyperuricaemia, hyperphosphataemia, hyperkalaemia and hypocalcaemia. TLSinduced renal failure is mainly caused by uric acid and calcium phosphate crystal deposition and usually develops following cytotoxic chemotherapy. Here, we present a case of spontaneous TLS in a patient with chronic myelomonocytic leukaemia (CMML) with massive uric acid stone and crystal formation and rapidly worsening renal failure. Autopsy revealed underlying tumourous kidney infiltration. Risk factors for occurrence of TLS and current therapeutic management are discussed.
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|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Nephrology
04 Faculty of Medicine > University Hospital Zurich > Institute of Surgical Pathology
|Dewey Decimal Classification:||610 Medicine & health|
|Deposited On:||23 Dec 2008 08:34|
|Last Modified:||23 Nov 2012 14:26|
|Publisher:||Oxford University Press|
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