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Dendritic cell derived cytokines in human natural killer cell differentiation and activation


Chijioke, Obinna; Münz, Christian (2013). Dendritic cell derived cytokines in human natural killer cell differentiation and activation. Frontiers in Immunology, 4:365.

Abstract

Dendritic cells (DCs) and natural killer (NK) cells shape each other's functions early during immune responses. DCs activate NK cells and NK cells can mature or kill DCs. In this review we will discuss which DC and NK cell subsets are mainly affected by this interaction, where these encounters might take place and which signals are exchanged. Finally, we will point out what the clinical benefit of understanding this interaction might be and how it changed our view on NK cells as innate lymphocytes.

Abstract

Dendritic cells (DCs) and natural killer (NK) cells shape each other's functions early during immune responses. DCs activate NK cells and NK cells can mature or kill DCs. In this review we will discuss which DC and NK cell subsets are mainly affected by this interaction, where these encounters might take place and which signals are exchanged. Finally, we will point out what the clinical benefit of understanding this interaction might be and how it changed our view on NK cells as innate lymphocytes.

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21 citations in Web of Science®
22 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2013
Deposited On:10 Feb 2014 10:12
Last Modified:05 Apr 2016 17:29
Publisher:Frontiers Research Foundation
ISSN:1664-3224
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.3389/fimmu.2013.00365
PubMed ID:24273539

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