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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-9055

Schachinger, H; Blumenthal, T D; Richter, S; Savaskan, E; Wirz-Justice, A; Kräuchi, K (2008). Melatonin reduces arousal and startle responsiveness without influencing startle habituation or affective startle modulation in young women. Hormones and Behavior, 54(2):258-262.

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Melatonin has been suggested to affect human emotion, but conflicting evidence exists. Therefore, we tested the effect of a single dose of a 4 mg prolonged release formulation of melatonin on a biologically based model of emotional processing. Affective modulation of acoustic white noise startle (103 dB) by emotional slides selected from the International Affective Picture System (IAPS) was assessed in 16 healthy young women twice, in a double-blind, placebo-controlled, balanced cross-over design. Melatonin significantly reduced startle responsiveness, but did not impact affective startle modulation, nor startle habituation. Melatonin significantly reduced arousal ratings and induced a parasympathetically dominated heart rate variability pattern indicative of a non-aroused state. We conclude that melatonin reduces arousal and startle responsiveness. However, no evidence for a direct emotion-modulating effect of melatonin was found in this healthy cohort.


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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Division of Psychiatric Research and Clinic for Psychogeriatric Medicine
Dewey Decimal Classification:610 Medicine & health
Date:10 April 2008
Deposited On:30 Dec 2008 17:10
Last Modified:05 Apr 2016 12:45
Publisher DOI:10.1016/j.yhbeh.2008.03.013
PubMed ID:18499110

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