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Activation of transposable elements during aging and neuronal decline in Drosophila


Li, Wanhe; Prazak, Lisa; Chatterjee, Nabanita; Grüninger, Servan; Krug, Lisa; Theodorou, Delphine; Dubnau, Josh (2013). Activation of transposable elements during aging and neuronal decline in Drosophila. Nature Neuroscience, 16(5):529-531.

Abstract

We found that several transposable elements were highly active in Drosophila brain during normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain, progressive and age-dependent memory impairment, and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function.

Abstract

We found that several transposable elements were highly active in Drosophila brain during normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain, progressive and age-dependent memory impairment, and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function.

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57 citations in Web of Science®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Neuroinformatics
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2013
Deposited On:13 Feb 2014 13:48
Last Modified:05 Apr 2016 17:33
Publisher:Nature Publishing Group
Series Name:Nature Neuroscience
Number of Pages:3
ISSN:1097-6256
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1038/nn.3368
PubMed ID:23563579

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