UZH-Logo

Maintenance Infos

Clinical and dermoscopic characteristics of desmoplastic melanomas


Jaimes, Natalia; Chen, Lucy; Dusza, Stephen W; Carrera, Cristina; Puig, Susana; Thomas, Luc; Kelly, John W; Dang, Lucy; Zalaudek, Iris; Braun, Ralph P; Menzies, Scott W; Busam, Klaus J; Marghoob, Ashfaq A (2013). Clinical and dermoscopic characteristics of desmoplastic melanomas. JAMA Dermatology, 149(4):413-421.

Abstract

OBJECTIVE: To describe and analyze the clinical and dermoscopic characteristics of desmoplastic melanoma (DM) as a function of pathologic subtype and phenotypic traits.
DESIGN: Retrospective case series.
SETTING: Eight high-risk dermatology clinics.
PATIENTS: Patients with DM confirmed by histopathologic analysis whose records included a high-quality dermoscopic image.
MAIN OUTCOME MEASURES: Clinical, dermoscopic, and histopathologic features of DM.
RESULTS: A total of 37 DM cases were identified. The majority of patients had fair skin, few nevi, and no history of melanoma. Lentigo maligna was the most frequent subtype of melanoma associated with DM. The most frequent clinical presentation of DM was a palpable and/or indurated lesion located on sun-exposed skin. Forty-three percent of cases were classified as pure DM, and 57% as mixed DM. Pure DM lesions were thicker than mixed DM lesions (4.10 vs 2.83 mm) (P = .22) and were less likely to have an associated epidermal non-DM component (63% vs 100%) (P = .004). Dermoscopically, DMs had at least 1 melanoma-specific structure, the most frequent being atypical vascular structures. Peppering was more frequently seen in pure DM (44% in pure DM vs 24% in mixed DM) (P = .29). In contrast, crystalline structures, polymorphous vessels, and vascular blush were more commonly seen in mixed DM.
CONCLUSIONS: Though DM can be difficult to diagnose based on clinical morphologic characteristics alone, dermoscopy has proved to be a useful aid during the evaluation of clinically equivocal lesions or those lesions with a benign appearance. The most common dermoscopic clues observed in DMs included atypical vascular structures, peppering, and occasionally other melanoma-specific structures.

Abstract

OBJECTIVE: To describe and analyze the clinical and dermoscopic characteristics of desmoplastic melanoma (DM) as a function of pathologic subtype and phenotypic traits.
DESIGN: Retrospective case series.
SETTING: Eight high-risk dermatology clinics.
PATIENTS: Patients with DM confirmed by histopathologic analysis whose records included a high-quality dermoscopic image.
MAIN OUTCOME MEASURES: Clinical, dermoscopic, and histopathologic features of DM.
RESULTS: A total of 37 DM cases were identified. The majority of patients had fair skin, few nevi, and no history of melanoma. Lentigo maligna was the most frequent subtype of melanoma associated with DM. The most frequent clinical presentation of DM was a palpable and/or indurated lesion located on sun-exposed skin. Forty-three percent of cases were classified as pure DM, and 57% as mixed DM. Pure DM lesions were thicker than mixed DM lesions (4.10 vs 2.83 mm) (P = .22) and were less likely to have an associated epidermal non-DM component (63% vs 100%) (P = .004). Dermoscopically, DMs had at least 1 melanoma-specific structure, the most frequent being atypical vascular structures. Peppering was more frequently seen in pure DM (44% in pure DM vs 24% in mixed DM) (P = .29). In contrast, crystalline structures, polymorphous vessels, and vascular blush were more commonly seen in mixed DM.
CONCLUSIONS: Though DM can be difficult to diagnose based on clinical morphologic characteristics alone, dermoscopy has proved to be a useful aid during the evaluation of clinically equivocal lesions or those lesions with a benign appearance. The most common dermoscopic clues observed in DMs included atypical vascular structures, peppering, and occasionally other melanoma-specific structures.

Citations

6 citations in Web of Science®
9 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

1 download since deposited on 12 Feb 2014
0 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2013
Deposited On:12 Feb 2014 15:14
Last Modified:05 Apr 2016 17:35
Publisher:American Medical Association
ISSN:2168-6068
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1001/jamadermatol.2013.2248
PubMed ID:23325288

Download

[img]
Filetype: PDF - Registered users only
Size: 486kB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations