Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-9278
Sigurdson, C J; Heikenwalder, M; Manco, G; Barthel, M; Schwarz, P; Stecher, B; Krautler, N J; Hardt, W D; Seifert, B; MacPherson, A J S; Corthesy, I; Aguzzi, A (2009). Bacterial Colitis Increases Susceptibility to Oral Prion Disease. Journal of Infectious Diseases, 199(2):243-252.
Dietary exposure to prion-contaminated materials has caused kuru and variant Creutzfeldt-Jakob disease in humans and transmissible spongiform encephalopathies (TSEs) in cattle, mink, and felines. The epidemiology of dietary prion infections suggests that host genetic modifiers and possibly exogenous cofactors may play a decisive role in determining disease susceptibility. However, few cofactors influencing susceptibility to prion infection have been identified. In the present study, we investigated whether colitis might represent one such cofactor. We report that moderate colitis caused by an attenuated Salmonella strain more than doubles the susceptibility of mice to oral prion infection and modestly accelerates the development of disease after prion challenge. The prion protein was up-regulated in intestines and mesenteric lymph nodes of mice with colitis, providing a possible mechanism for the effect of colitis on the pathogenesis of prion disease. Therefore, moderate intestinal inflammation at the time of prion exposure may constitute one of the elusive risk factors underlying the development of TSE.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Social and Preventive Medicine|
04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||08 Jan 2009 15:06|
|Last Modified:||27 Nov 2013 22:38|
|Publisher:||University of Chicago Press|
|Additional Information:||© 2008 by The Journal of Infectious Diseases.|
|Citations:||Web of Science®. Times Cited: 12|
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