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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-933

Moreno, E; Basler, K (2004). dMyc transforms cells into super-competitors. Cell, 117(1):117-129.

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Abstract

Overexpression of myc protooncogenes has been implicated in the genesis of many human tumors. Myc proteins seem to regulate diverse biological processes, but their role in tumorigenesis remains enigmatic. Here we use Drosophila imaginal discs to mimic situations in which cells with unequal levels of Myc protein are apposed and show that this invariably elicits a win/lose situation reminiscent of cell competition; cells with lower levels of dMyc are eliminated by apoptosis whereas cells with higher levels of dMyc over-proliferate. We find that this competitive behavior correlates with, and can be corrected by, the activation of the BMP/Dpp survival signaling pathway. Hence the heritable increase in dMyc levels causes cells to behave as "super-competitors" and reveals a novel mode of clonal expansion that causes, but also relies on, the killing of surrounding cells.

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:2 April 2004
Deposited On:11 Feb 2008 12:19
Last Modified:28 Nov 2013 02:06
Publisher:Elsevier
ISSN:0092-8674
Publisher DOI:10.1016/S0092-8674(04)00262-4
PubMed ID:15066287
Citations:Web of Science®. Times Cited: 208
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