Lettre, G; Kritikou, E A; Jaeggi, M; Calixto, A; Fraser, A G; Kamath, R S; Ahringer, J; Hengartner, M O (2004). Genome-wide RNAi identifies p53-dependent and -independent regulators of germ cell apoptosis in C. elegans. Cell Death and Differentiation, 11(11):1198-1203.
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We used genome-wide RNA interference (RNAi) to identify genes that affect apoptosis in the C. elegans germ line. RNAi-mediated knockdown of 21 genes caused a moderate to strong increase in germ cell death. Genetic epistasis studies with these RNAi candidates showed that a large subset (16/21) requires p53 to activate germ cell apoptosis. Apoptosis following knockdown of the genes in the p53-dependent class also depended on a functional DNA damage response pathway, suggesting that these genes might function in DNA repair or to maintain genome integrity. As apoptotic pathways are conserved, orthologues of the worm germline apoptosis genes presented here could be involved in the maintenance of genomic stability, p53 activation, and fertility in mammals.
|Item Type:||Journal Article, refereed|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|DDC:||570 Life sciences; biology|
|Date:||01 November 2004|
|Deposited On:||11 Feb 2008 13:19|
|Last Modified:||27 Nov 2013 23:46|
|Publisher:||Nature Publishing Group|
|Citations:||Web of Science®. Times cited: 52|
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