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Navigator based respiratory gating during acquisition and preparation phases for proton liver spectroscopy at 3 T


Hock, Andreas; Valkovič, Ladislav; Geier, Andreas; Kuntzen, Thomas; Boesiger, Peter; Henning, Anke (2014). Navigator based respiratory gating during acquisition and preparation phases for proton liver spectroscopy at 3 T. NMR in Biomedicine, 27(3):348-355.

Abstract

Proton magnetic resonance spectroscopy (1H MRS) enables the non-invasive investigation of the human liver; however, because of technical difficulties it is not regularly used for diagnosis of liver diseases in clinical routine. Breathing motion is one of the major challenges, as it decreases spectral quality and leads to misplacement of the spectroscopic voxel. To overcome this problem, real-time navigator gating for spectral acquisition and preparation steps (B0 shimming, water frequency determination, receiver gain optimization, and water suppression) combined with short TE, optimized first order projection based B0 shimming, water suppression, and inner-volume saturated point resolved spectroscopy (PRESS) at 3 T is suggested. Simultaneous lipid and trimethylamine quantification is demonstrated by means of phantom, volunteer, and representative patient measurements. Precise localization of the voxel despite respiratory motion, increased spectral quality (higher signal-to-noise ratio and reduced linewidth) compared with measurements without respiratory gating, and the possibility of acquiring data without additional subject instructions regarding breathing enable robust and accurate liver 1H MRS measurements with this novel acquisition protocol.

Abstract

Proton magnetic resonance spectroscopy (1H MRS) enables the non-invasive investigation of the human liver; however, because of technical difficulties it is not regularly used for diagnosis of liver diseases in clinical routine. Breathing motion is one of the major challenges, as it decreases spectral quality and leads to misplacement of the spectroscopic voxel. To overcome this problem, real-time navigator gating for spectral acquisition and preparation steps (B0 shimming, water frequency determination, receiver gain optimization, and water suppression) combined with short TE, optimized first order projection based B0 shimming, water suppression, and inner-volume saturated point resolved spectroscopy (PRESS) at 3 T is suggested. Simultaneous lipid and trimethylamine quantification is demonstrated by means of phantom, volunteer, and representative patient measurements. Precise localization of the voxel despite respiratory motion, increased spectral quality (higher signal-to-noise ratio and reduced linewidth) compared with measurements without respiratory gating, and the possibility of acquiring data without additional subject instructions regarding breathing enable robust and accurate liver 1H MRS measurements with this novel acquisition protocol.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
04 Faculty of Medicine > University Hospital Zurich > Clinic for Gastroenterology and Hepatology
04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Language:English
Date:2014
Deposited On:04 Mar 2014 16:00
Last Modified:05 Apr 2016 17:44
Publisher:Wiley-Blackwell
ISSN:0952-3480
Funders:University of Zurich, Slovak Grant Agency VEGA (grant 2/0013/14), SPP foundation grant program Hlavicka (92/2010)
Publisher DOI:https://doi.org/10.1002/nbm.3069

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