Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-952
Gumienny, T L; Brugnera, E; Tosello-Trampont, A C; Kinchen, J M; Haney, L B; Nishiwaki, K; Walk, S F; Nemergut, M E; Macara, I G; Francis, R; Schedl, T; Qin, Y; Van Aelst, L; Hengartner, M O; Ravichandran, K S (2001). CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Cell, 107(1):27-41.
The C. elegans genes ced-2, ced-5, and ced-10, and their mammalian homologs crkII, dock180, and rac1, mediate cytoskeletal rearrangements during phagocytosis of apoptotic cells and cell motility. Here, we describe an additional member of this signaling pathway, ced-12, and its mammalian homologs, elmo1 and elmo2. In C. elegans, CED-12 is required for engulfment of dying cells and for cell migrations. In mammalian cells, ELMO1 functionally cooperates with CrkII and Dock180 to promote phagocytosis and cell shape changes. CED-12/ELMO-1 binds directly to CED-5/Dock180; this evolutionarily conserved complex stimulates a Rac-GEF, leading to Rac1 activation and cytoskeletal rearrangements. These studies identify CED-12/ELMO as an upstream regulator of Rac1 that affects engulfment and cell migration from C. elegans to mammals.
|Item Type:||Journal Article, refereed|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|DDC:||570 Life sciences; biology|
|Date:||05 October 2001|
|Deposited On:||11 Feb 2008 13:19|
|Last Modified:||27 Nov 2013 17:36|
|Citations:||Web of Science®. Times Cited: 262|
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