Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-952
Gumienny, T L; Brugnera, E; Tosello-Trampont, A C; Kinchen, J M; Haney, L B; Nishiwaki, K; Walk, S F; Nemergut, M E; Macara, I G; Francis, R; Schedl, T; Qin, Y; Van Aelst, L; Hengartner, M O; Ravichandran, K S (2001). CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Cell, 107(1):27-41.
View at publisher
The C. elegans genes ced-2, ced-5, and ced-10, and their mammalian homologs crkII, dock180, and rac1, mediate cytoskeletal rearrangements during phagocytosis of apoptotic cells and cell motility. Here, we describe an additional member of this signaling pathway, ced-12, and its mammalian homologs, elmo1 and elmo2. In C. elegans, CED-12 is required for engulfment of dying cells and for cell migrations. In mammalian cells, ELMO1 functionally cooperates with CrkII and Dock180 to promote phagocytosis and cell shape changes. CED-12/ELMO-1 binds directly to CED-5/Dock180; this evolutionarily conserved complex stimulates a Rac-GEF, leading to Rac1 activation and cytoskeletal rearrangements. These studies identify CED-12/ELMO as an upstream regulator of Rac1 that affects engulfment and cell migration from C. elegans to mammals.
55 downloads since deposited on 11 Feb 2008
13 downloads since 12 months
|Item Type:||Journal Article, refereed|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|Dewey Decimal Classification:||570 Life sciences; biology|
|Date:||5 October 2001|
|Deposited On:||11 Feb 2008 12:19|
|Last Modified:||27 Nov 2013 16:36|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page