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Gumienny, T L; Hengartner, M O (2001). How the worm removes corpses: the nematode C. elegans as a model system to study engulfment. Cell Death and Differentiation, 8(6):564-568.

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Abstract

Apoptotic cell death in the nematode C. elegans culminates with the removal of the dying cells from the organism. This removal is brought forth through a rapid and specific engulfment of the doomed cell by one of its neighbors. Over half a dozen genes have been identified that function in this process in the worm. Many of these engulfment genes have functional homologs in Drosophila and higher vertebrates. Indeed, there is growing evidence supporting the hypothesis that the pathways that mediate the removal of apoptotic cells might be, at least in part, conserved through evolution.

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:01 June 2001
Deposited On:11 Feb 2008 13:19
Last Modified:23 Nov 2012 15:27
Publisher:Nature Publishing Group
ISSN:1350-9047
Publisher DOI:10.1038/sj/cdd/4400850
PubMed ID:11536006
Citations:Google Scholarā„¢

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