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Konformationsanalysen von Modell-Tripeptiden: Der Einfluss von alpha,alpha-disubstituierten alpha-Aminosäuren auf die Sekundärstruktur. Teil II. Röntgenstrukturanalyse und Konformationsenergie-Berechnungen


Wipf, Peter; Kunz, Roland W; Prewo, Roland; Heimgartner, Heinz (1988). Konformationsanalysen von Modell-Tripeptiden: Der Einfluss von alpha,alpha-disubstituierten alpha-Aminosäuren auf die Sekundärstruktur. Teil II. Röntgenstrukturanalyse und Konformationsenergie-Berechnungen. Helvetica Chimica Acta, 71(1):268-273.

Abstract

Conformational Analysis of Tripeptide Models: The Influence of alpha,alpha-disubstituted alpha-Amino Acids on the Secondary Structure. X-Ray Analysis and Conformational Energy Calculations
The X-ray analysis of tripeptide Z-Ile-Val(2-Me)-benzocaine (1f) reveals the presence of a type-III beta-turn. Moreover, MMP2 calculations on tripeptides, e.g. Z-Ile-Aib-benzocaine (1c), Z-Ile-D-Val(2-Me)-benzocaine (1g), Z-Ile-Gly(2,2-Pr2)-benzocaine (1h), Z-Ile-Gly-benzocaine (1a), and 1f, fit well into the frame of NMR and CD investigations. They allow considerations on the relative stability of different types of beta-turns dependig on the peptide sequence, e.g. the kind of alpha,alpha-disubstituted amino-acid moieties.

Conformational Analysis of Tripeptide Models: The Influence of alpha,alpha-disubstituted alpha-Amino Acids on the Secondary Structure. X-Ray Analysis and Conformational Energy Calculations
The X-ray analysis of tripeptide Z-Ile-Val(2-Me)-benzocaine (1f) reveals the presence of a type-III beta-turn. Moreover, MMP2 calculations on tripeptides, e.g. Z-Ile-Aib-benzocaine (1c), Z-Ile-D-Val(2-Me)-benzocaine (1g), Z-Ile-Gly(2,2-Pr2)-benzocaine (1h), Z-Ile-Gly-benzocaine (1a), and 1f, fit well into the frame of NMR and CD investigations. They allow considerations on the relative stability of different types of beta-turns dependig on the peptide sequence, e.g. the kind of alpha,alpha-disubstituted amino-acid moieties.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:German
Date:1988
Deposited On:14 May 2014 09:12
Last Modified:05 Apr 2016 17:50
Publisher:Wiley-Blackwell
ISSN:0018-019X
Publisher DOI:https://doi.org/10.1002/hlca.19880710130
Permanent URL: https://doi.org/10.5167/uzh-95393

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