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Carboxy-terminated oligo(ethylene glycol)-alkane phosphate: synthesis and self-assembly on titanium oxide surfaces


Gnauck, Mandy; Jaehne, Evelin; Blaettler, Thomas; Tosatti, Samuele; Textor, Marcus; Adler, Hans-Juergen P (2007). Carboxy-terminated oligo(ethylene glycol)-alkane phosphate: synthesis and self-assembly on titanium oxide surfaces. Langmuir, 23(2):377-381.

Abstract

The surface immobilization of oligo- and poly(ethylene glycol) on solids is a widely used approach to prevent the nonspecific adsorption of proteins, bacteria, and cells. A novel tri(ethylene glycol) derivative, phosphoric acid-mono(22-carboxy-12,15,18,21-tetraoxadocosyl) ester, was synthesized with the aim to produce self-assembled monolayers (SAMs) on metal/metal oxide surfaces. This compound contains two reactive, terminal moieties: the phosphoric acid group as anchor to the surface, and the carboxylic group as linker for further attachment of molecules such as peptides and proteins to be present at the surface. The adsorption on titanium-dioxide-coated substrates was studied quantitatively and the resulting SAMs were characterized by angle-dependent X-ray photoelectron spectroscopy (XPS) and spectroscopic ellipsometry. XPS data showed that the monomolecular layer is attached with the phosphate group to the substrate, but not fully ordered. The dry adlayer thickness was determined to be 13.4 A, which is less than expected for a densely packed monolayer. Surface concentration calculated from ellipsometry data resulted in a grafting density of 2.03 molecules/nm2.

The surface immobilization of oligo- and poly(ethylene glycol) on solids is a widely used approach to prevent the nonspecific adsorption of proteins, bacteria, and cells. A novel tri(ethylene glycol) derivative, phosphoric acid-mono(22-carboxy-12,15,18,21-tetraoxadocosyl) ester, was synthesized with the aim to produce self-assembled monolayers (SAMs) on metal/metal oxide surfaces. This compound contains two reactive, terminal moieties: the phosphoric acid group as anchor to the surface, and the carboxylic group as linker for further attachment of molecules such as peptides and proteins to be present at the surface. The adsorption on titanium-dioxide-coated substrates was studied quantitatively and the resulting SAMs were characterized by angle-dependent X-ray photoelectron spectroscopy (XPS) and spectroscopic ellipsometry. XPS data showed that the monomolecular layer is attached with the phosphate group to the substrate, but not fully ordered. The dry adlayer thickness was determined to be 13.4 A, which is less than expected for a densely packed monolayer. Surface concentration calculated from ellipsometry data resulted in a grafting density of 2.03 molecules/nm2.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Language:English
Date:2007
Deposited On:28 Apr 2014 09:18
Last Modified:05 Apr 2016 17:51
Publisher:American Chemical Society
ISSN:0743-7463
Publisher DOI:https://doi.org/10.1021/la0606648
PubMed ID:17209580

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