Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Hüsler, M R; Wilson, R D; Rychik, J; Bebbington, M W; Johnson, M P; Mann, S E; Hedrick, H L; Adzick, N S (2007). Prenatally diagnosed fetal lung lesions with associated conotruncal heart defects: is there a genetic association? Prenatal Diagnosis, 27(12):1123-1128.

Full text not available from this repository.

View at publisher

Abstract

Congenital lung malformation can easily be diagnosed by prenatal ultrasound. Associated extrapulmonary malformations such as heart defects and chromosomal aberrations are rare.OBJECTIVE: The objective of this study was to describe the natural history, outcome and other associated malformations in fetuses with lung lesions and an associated heart defect. METHODS: Retrospective analysis of 4 cases of prenatally diagnosed fetal CCAMs and hybrid lesions with an associated heart defect and review of 8 cases in the literature. RESULTS: At a single referral center 1.9% of the fetuses with Congenital cystic adenomatoid malformation (CCAM) were diagnosed with an associated heart defect. Seven of the total 12 cases (58%) reviewed had a conotruncal heart abnormality. Chromosomal abnormalities were found in 5 (42%) of the cases. CONCLUSION: This retrospective review shows that karyotyping in fetal lung lesions with an associated heart defect or isolated large lung lesions is indicated. It also suggests that there is a subpopulation of fetuses with CCAMs who have conotruncal heart defects. This finding may suggest a common genetic background.

Citations

3 citations in Web of Science®
5 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Obstetrics
DDC:610 Medicine & health
Language:English
Date:2007
Deposited On:24 Feb 2010 08:23
Last Modified:27 Nov 2013 19:52
Publisher:Wiley-Blackwell
ISSN:0197-3851
Publisher DOI:10.1002/pd.1845
PubMed ID:17787025

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page