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A molecular view of multiple sclerosis and experimental autoimmune encephalitis: what can we learn from the epitope data?


Vaughan, K; Peters, B; O'Connor, K; Martin, R; Sette, A (2014). A molecular view of multiple sclerosis and experimental autoimmune encephalitis: what can we learn from the epitope data? Journal of Neuroimmunology, 267(1-2):73-85.

Abstract

An analysis to inventory all immune epitope data related to multiple sclerosis (MS) was performed using the Immune Epitope Database (IEDB). The analysis revealed that MS related data represent >20% of all autoimmune data, and that studies of EAE predominate; only 22% of the references describe human data. To date, >5800 unique peptides, analogs, mimotopes, and/or non-protein epitopes have been reported from 861 references, including data describing myelin-containing, as well as non-myelin antigens. This work provides a reference point for the scientific community of the universe of available data for MS-related adaptive immunity in the context of EAE and human disease.

An analysis to inventory all immune epitope data related to multiple sclerosis (MS) was performed using the Immune Epitope Database (IEDB). The analysis revealed that MS related data represent >20% of all autoimmune data, and that studies of EAE predominate; only 22% of the references describe human data. To date, >5800 unique peptides, analogs, mimotopes, and/or non-protein epitopes have been reported from 861 references, including data describing myelin-containing, as well as non-myelin antigens. This work provides a reference point for the scientific community of the universe of available data for MS-related adaptive immunity in the context of EAE and human disease.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2014
Deposited On:13 May 2014 16:07
Last Modified:05 Apr 2016 17:51
Publisher:Elsevier
ISSN:0165-5728
Publisher DOI:https://doi.org/10.1016/j.jneuroim.2013.12.009
PubMed ID:24365494
Permanent URL: https://doi.org/10.5167/uzh-95743

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