Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-959

Peter, M E; Heufelder, A E; Hengartner, M O (1997). Advances in apoptosis research. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 94(24):12736-12737.

[img]
Preview
PDF
199kB

Abstract

Apoptosis, also called programmed cell death, has attracted great attention in recent years. After its discovery by Carl Vogt in 1842, apoptosis research was dormant for more than a century. Its rediscovery in the second half of this century, and the coining of the term apoptosis in 1972 by Kerr, Wyllie, and Currie, ignited an unparalleled interest in this field of science. The number of publications related to apoptosis has been growing exponentially every year ever since. This is mainly due to three major advances, two of which have been made recently and one that is currently seen. First, studies with the small nematode Caenorhabditis elegans have identified a number of apoptosis regulating genes--the first evidence that cell death is an active process under genetic control. Many of these genes have mammalian homologs that, like their worm counterparts, seem to regulate mammalian apoptosis. Second, elucidation of the signal transduction pathways of apoptosis has lead especially to the identification of specific death signaling molecules such as a new family of cysteine proteases, the caspases. Third, it has now become clear that many diseases are characterized by dysregulation of apoptotic programs. Many of these programs involve a family of receptors and their ligands, the death receptor/ligand family. The hope now is to interfere with apoptosis regulation in these systems and to develop new therapeutic concepts.

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:25 November 1997
Deposited On:11 Feb 2008 12:19
Last Modified:28 Nov 2013 02:06
Publisher:National Academy of Sciences
ISSN:0027-8424
Publisher DOI:10.1073/pnas.94.24.12736
Related URLs:http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=34166&rendertype=abstract
PubMed ID:9398063
Citations:Web of Science®. Times Cited: 128
Google Scholar™

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page