Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-964

Gerlitz, O; Basler, K (2002). Wingful, an extracellular feedback inhibitor of wingless. Genes and Development, 16(9):1055-1059.

[img]
Preview
PDF
655kB

Abstract

Secreted peptide signals control many fundamental processes during animal development. Proper responses to these signals require cognate inducible feedback antagonists. Here we report the identification of a novel Drosophila Wingless (Wg) target gene, wingful (wf), and show that it encodes a potent extracellular feedback inhibitor of Wg. In contrast to the cytoplasmic protein Naked cuticle (Nkd), the only known Wg feedback antagonist, Wf functions during larval stages, when Nkd function is dispensable. We propose that Wf may provide feedback control for the long-range morphogen activities of Wg.

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:2002
Deposited On:11 Feb 2008 12:19
Last Modified:27 Nov 2013 20:16
Publisher:Cold Spring Harbor Laboratory Press
ISSN:0890-9369
Publisher DOI:10.1101/gad.991802
PubMed ID:12000788
Citations:Web of Science®. Times Cited: 68
Google Scholar™

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page