Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-9667

Roiser, J P; Levy, J; Fromm, S J; Wang, H; Hasler, G; Sahakian, B J; Drevets, W C (2008). The effect of acute tryptophan depletion on the neural correlates of emotional processing in healthy volunteers. Neuropsychopharmacology, 33(8):1992-2006.

[img] PDF - Registered users only
View at publisher


The processing of affective material is known to be modulated by serotonin (5-HT), but few studies have used neurophysiological measures to characterize the effect of changes in 5-HT on neural responses to emotional stimuli. We used functional magnetic resonance imaging to investigate the effect of acute tryptophan depletion, which reduces central 5-HT synthesis, on neural responses to emotionally valenced verbal stimuli. Though no participants experienced significant mood change, emotional information processing was substantially modified following 5-HT depletion. A behavioral bias toward positive stimuli was attenuated following depletion, which was accompanied by increased hemodynamic responses during the processing of emotional words in several subcortical structures. Inter-individual differences in tryptophan depletion-elicited anxiety correlated positively with the caudate bias toward negative stimuli. These data suggest that 5-HT may play an important role in mediating automatic negative attentional biases in major depression, as well as resilience against negative distracting stimuli in never-depressed individuals.


39 citations in Web of Science®
45 citations in Scopus®
Google Scholar™



1 download since deposited on 08 Jan 2009
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Psychiatry and Psychotherapy
Dewey Decimal Classification:610 Medicine & health
Deposited On:08 Jan 2009 09:40
Last Modified:05 Apr 2016 12:47
Publisher:Nature Publishing Group
ISSN:0893-133X (P) 1470-634X (E)
Publisher DOI:10.1038/sj.npp.1301581
PubMed ID:17882232

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page