Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-9667
Roiser, J P; Levy, J; Fromm, S J; Wang, H; Hasler, G; Sahakian, B J; Drevets, W C (2008). The effect of acute tryptophan depletion on the neural correlates of emotional processing in healthy volunteers. Neuropsychopharmacology, 33(8):1992-2006.
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The processing of affective material is known to be modulated by serotonin (5-HT), but few studies have used neurophysiological measures to characterize the effect of changes in 5-HT on neural responses to emotional stimuli. We used functional magnetic resonance imaging to investigate the effect of acute tryptophan depletion, which reduces central 5-HT synthesis, on neural responses to emotionally valenced verbal stimuli. Though no participants experienced significant mood change, emotional information processing was substantially modified following 5-HT depletion. A behavioral bias toward positive stimuli was attenuated following depletion, which was accompanied by increased hemodynamic responses during the processing of emotional words in several subcortical structures. Inter-individual differences in tryptophan depletion-elicited anxiety correlated positively with the caudate bias toward negative stimuli. These data suggest that 5-HT may play an important role in mediating automatic negative attentional biases in major depression, as well as resilience against negative distracting stimuli in never-depressed individuals.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Psychiatry and Psychotherapy|
|DDC:||610 Medicine & health|
|Deposited On:||08 Jan 2009 09:40|
|Last Modified:||27 Nov 2013 18:46|
|Publisher:||Nature Publishing Group|
|ISSN:||0893-133X (P) 1470-634X (E)|
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