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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-9669

Boot, E; Booij, J; Hasler, G; Zinkstok, J R; de Haan, L; Linszen, D H; van Amelsvoort, T A (2008). AMPT-induced monoamine depletion in humans: evaluation of two alternative (123I)IBZM SPECT procedures. European Journal of Nuclear Medicine and Molecular Imaging, 35(7):1350-1356.

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Abstract

Purpose
Acute monoamine depletion paradigms using alpha-methyl-para-tyrosine (AMPT) combined with single photon emission computed tomography (SPECT) have been used successfully to evaluate disturbances in central dopaminergic neurotransmission. However, severe side effects due to relatively high doses (4,500 to 8,000 mg) of AMPT have been reasons for study withdrawal. Thus, we assessed the effectiveness and tolerability of two alternative procedures, using lower doses of AMPT.

Methods
Six healthy subjects underwent three measurements of striatal dopamine D2 receptor (D2R)-binding potential (BPND) with SPECT and the selective radiolabeled D2R antagonist [123I]IBZM. All subjects were scanned in the absence of pharmacological intervention (baseline) and after two different depletion procedures. In the first depletion session, over 6 h, subjects were administered 1,500 mg of AMPT before scanning. In the second depletion session, over 25 h, subjects were administered 40 mg AMPT/kg body weight. We also administered the Subjective Well-being Under Neuroleptic Treatment Scale, a self-report instrument designed to measure the subjective experience of patients on neuroleptic medication.

Results
We found no change of mean D2R BPND after the first and short AMPT challenge compared to the baseline. However, we found a significant increase in striatal D2R BPND binding after the AMPT challenge adjusted for bodyweight compared to both other regimen. Although subjective well-being worsened after the prolonged AMPT challenge, no severe side effects were reported.

Conclusions
Our results imply a low-dosage, suitable alternative to the common AMPT procedure. The probability of side effects and study withdrawal can be reduced by this procedure.

Citations

9 citations in Web of Science®
12 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Psychiatry and Psychotherapy
DDC:610 Medicine & health
Language:English
Date:2008
Deposited On:07 Jan 2009 10:22
Last Modified:27 Nov 2013 21:49
Publisher:Springer
ISSN:1619-7070
Publisher DOI:10.1007/s00259-008-0739-8
PubMed ID:18283451

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