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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-9670

Pinto, A; Greenberg, B D; Grados, M A; Bienvenu 3rd, O J; Samuels, J F; Murphy, D L; Hasler, G; Stout, R L; Rauch, S L; Shugart, Y Y; Pauls, D L; Knowles, J A; Fyer, A J; McCracken, J T; Piacentini, J; Wang, Y; Willour, V L; Cullen, B; Liang, K Y; Hoehn-Saric, R; Riddle, M A; Rasmussen, S A; Nestadt, G (2008). Further development of YBOCS dimensions in the OCD collaborative genetics study: symptoms vs. categories. Psychiatry Research, 160(1):83-93.

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Abstract

Despite progress in identifying homogeneous subphenotypes of obsessive-compulsive disorder (OCD) through factor analysis of the Yale Brown Obsessive-Compulsive Scale Symptom Checklist (YBOCS-SC), prior solutions have been limited by a reliance on presupposed symptom categories rather than discrete symptoms. Furthermore, there have been few attempts to evaluate the familiality of OCD symptom dimensions. The purpose of this study was to extend prior work by this collaborative group in category-based dimensions by conducting the first-ever exploratory dichotomous factor analysis using individual OCD symptoms, comparing these results to a refined category-level solution, and testing the familiality of derived factors. Participants were 485 adults in the six-site OCD Collaborative Genetics Study, diagnosed with lifetime OCD using semi-structured interviews. YBOCS-SC data were factor analyzed at both the individual item and symptom category levels. Factor score intraclass correlations were calculated using a subsample of 145 independent affected sib pairs. The item- and category-level factor analyses yielded nearly identical 5-factor solutions. While significant sib-sib associations were found for four of the five factors, Hoarding and Taboo Thoughts were the most robustly familial (r ICC>or=0.2). This report presents considerable converging evidence for a five-factor structural model of OCD symptoms, including separate factor analyses employing individual symptoms and symptom categories, as well as sibling concordance. The results support investigation of this multidimensional model in OCD genetic linkage studies.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Psychiatry and Psychotherapy
DDC:610 Medicine & health
Language:English
Date:2008
Deposited On:08 Jan 2009 08:31
Last Modified:27 Nov 2013 18:23
Publisher:Elsevier
ISSN:0165-1781
Publisher DOI:10.1016/j.psychres.2007.07.010
PubMed ID:18514325
Citations:Web of Science®. Times Cited: 50
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Scopus®. Citation Count: 58

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