Quick Search:

uzh logo
Browse by:


Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-9671

Hasler, G; van der Veen, J W; Geraci, M; Shen, J; Pine, D; Drevets, W C (2009). Prefrontal Cortical Gamma-Aminobutyric Acid Levels in Panic Disorder Determined by Proton Magnetic Resonance Spectroscopy. Biological Psychiatry, 65(3):273-275.

Accepted Version
View at publisher


BACKGROUND: Panic disorder (PD) is hypothesized to be associated with altered function of the major inhibitory neurotransmitter, gamma-aminobutyric acid (GABA). Previous proton magnetic resonance spectroscopy (MRS) studies found lower GABA concentrations in the occipital cortex of subjects with PD relative to healthy control subjects. The current study is the first MRS study to compare GABA concentrations between unmedicated PD subjects and control subjects in the prefrontal cortex (PFC). METHODS: Unmedicated subjects with PD (n = 17) and age- and sex-matched healthy control subjects (n = 17) were scanned on a 3 Tesla scanner using a transmit-receive head coil that provided a sufficiently homogenous radiofrequency field to obtain spectroscopic measurements in the dorsomedial/dorsal anterolateral and ventromedial areas of the PFC. RESULTS: The prefrontal cortical GABA concentrations did not differ significantly between PD subjects and control subjects. There also was no statistically significant difference in glutamate/glutamine (Glx), choline, or N-acetyl aspartate concentrations. CONCLUSIONS: The previously reported finding of reduced GABA concentrations in the occipital cortex of PD subjects does not appear to extend to the PFC.


26 citations in Web of Science®
28 citations in Scopus®
Google Scholar™



275 downloads since deposited on 07 Jan 2009
23 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Psychiatry and Psychotherapy
Dewey Decimal Classification:610 Medicine & health
Date:February 2009
Deposited On:07 Jan 2009 13:47
Last Modified:27 Nov 2013 22:06
Publisher DOI:10.1016/j.biopsych.2008.06.023
PubMed ID:18692172

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page