Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-9739
Biver, S; Belge, H; Bourgeois, S; Van Vooren, P; Nowik, M; Scohy, S; Houillier, P; Szpirer, J; Szpirer, C; Wagner, C A; Devuyst, O; Marini, A M (2008). A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility. Nature, 456(7220):339-343.
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The kidney has an important role in the regulation of acid-base homeostasis. Renal ammonium production and excretion are essential for net acid excretion under basal conditions and during metabolic acidosis. Ammonium is secreted into the urine by the collecting duct, a distal nephron segment where ammonium transport is believed to occur by non-ionic NH(3) diffusion coupled to H(+) secretion. Here we show that this process is largely dependent on the Rhesus factor Rhcg. Mice lacking Rhcg have abnormal urinary acidification due to impaired ammonium excretion on acid loading-a feature of distal renal tubular acidosis. In vitro microperfused collecting ducts of Rhcg(-/-) acid-loaded mice show reduced apical permeability to NH(3) and impaired transepithelial NH(3) transport. Furthermore, Rhcg is localized in epididymal epithelial cells and is required for normal fertility and epididymal fluid pH. We anticipate a critical role for Rhcg in ammonium handling and pH homeostasis both in the kidney and the male reproductive tract.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Center for Integrative Human Physiology|
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Date:||20 November 2008|
|Deposited On:||06 Jan 2009 12:32|
|Last Modified:||23 Nov 2012 13:50|
|Publisher:||Nature Publishing Group|
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