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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-9740

Thomas, M A; Langenegger, T; Velan, S S; Nagarajan, R; Raman, S; Gomez, A; Margolis, D; Swart, S; Raylman, R R; Schulte, R F; Boesiger, P (2008). Two-dimensional MR spectroscopy of healthy and cancerous prostates in vivo. Magnetic Resonance Materials in Physics Biology and Medicine, 21(6):443-458.

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OBJECTIVES: A major goal of this article is to summarize the current status of evaluating prostate metabolites non-invasively using spatially resolved two-dimensional (2D) MR Spectroscopy (MRS). MATERIALS AND METHODS: Due to various technical challenges, the spatially resolved versions of 2D MRS techniques are currently going through the developmental stage. During the last decade, four different versions of 2D MRS sequences have been successfully implemented on 3T and 1.5T MRI scanners manufactured by three different vendors. These sequences include half and maximum echo sampled J-resolved spectroscopy (JPRESS), S-PRESS and L-COSY, which are single volume localizing sequences, and the multi-voxel based JPRESS sequence. RESULTS: Even though greater than 1ml voxels have been used, preliminary evaluations of 2D JPRESS, S-PRESS and L-COSY sequences have demonstrated unambiguous detection of citrate, creatine, choline, spermine and more metabolites in human prostates. ProFIT-based quantitation of JPRESS and L-COSY data clearly shows the superiority of 2D MRS over conventional one-dimensional (1D) MRS and more than six metabolites have been successfully quantified. These sequences have been evaluated in a small group of prostate pathologies and pilot investigations using these sequences show promising results in prostate pathologies. CONCLUSION: Implementation of the state-of-the-art 2D MRS techniques and preliminary evaluation in prostate pathologies are discussed in this review. Even though these techniques are going through developmental and early testing phases, it is evident that 2D MRS can be easily added on to any clinical Magnetic Resonance Imaging (MRI) protocol to non-invasively record the biochemical contents of the prostate.


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Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Deposited On:20 Jan 2009 16:51
Last Modified:05 Apr 2016 12:48
Publisher DOI:10.1007/s10334-008-0121-7
PubMed ID:18633659

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