Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-9764
Carraro, G E; Russi, E W; Buechi, S; Bloch, K E (2009). Does oral alprazolam affect ventilation? a randomised, double-blind, placebo-controlled trial. Journal of Psychopharmacology, 23(3):322-327.
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The respiratory effects of benzodiazepines have been controversial. This investigation aimed to study the effects of oral alprazolam on ventilation. In a randomised, double-blind cross-over protocol, 20 healthy men ingested 1 mg of alprazolam or placebo in random order, 1 week apart. Ventilation was unobtrusively monitored by inductance plethysmography along with end-tidal PCO2 and pulse oximetry 60-160 min after drug intake. Subjects were encouraged to keep eyes open. Meanï¿(1/2)+/- was similar (6.21 +/- 0.71 vs 6.41 +/- 1.12 L/min, P = NS). End-tidal PCO2 and oxygen saturation did also not differ between treatments. However, coefficients of variation of minute ventilation after alprazolam exceeded those after placebo (43 +/- 23% vs 31 +/- 13%, P < 0.05). More encouragements to keep eyes open were required after alprazolam than after placebo (5.2 +/- 5.7 vs 1.3 +/- 2.3 calls, P < 0.05). In a multiple regression analysis, higher coefficients of variation of minute ventilation after alprazolam were related to a greater number of calls. Oral alprazolam in a mildly sedative dose has no clinically relevant effect on ventilation in healthy, awake men. The increased variability of ventilation on alprazolam seems related to vigilance fluctuations rather than to a direct drug effect on ventilation.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Pneumology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Psychiatry and Psychotherapy
|DDC:||610 Medicine & health|
|Deposited On:||09 Jan 2009 09:35|
|Last Modified:||27 Nov 2013 23:41|
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