Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-9829
Bragg, J G; Wagner, A (2009). Protein material costs: single atoms can make an evolutionary difference. Trends in Genetics, 25(1):5-8.
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The process of gene expression has material costs caused by the quantities of carbon, nitrogen, sulfur and phosphorus that are needed to make mRNAs and proteins. When any such chemical element is ecologically limiting, mutations increasing these costs can reduce growth. Here, we ask if such mutations are 'visible' to natural selection in the yeast Saccharomyces cerevisiae. We find that mutations causing small increases in expression and even single amino acid replacements can be subject to natural selection on the basis of their material costs.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Department of Biochemistry
07 Faculty of Science > Department of Biochemistry
Special Collections > SystemsX.ch
Special Collections > SystemsX.ch > Research, Technology and Development Projects > YeastX
|DDC:||570 Life sciences; biology|
|Deposited On:||08 Jan 2009 11:10|
|Last Modified:||28 Nov 2013 00:32|
|Citations:||Web of Science®. Times Cited: 23|
Scopus®. Citation Count: 23
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