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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-9829

Bragg, J G; Wagner, A (2009). Protein material costs: single atoms can make an evolutionary difference. Trends in Genetics, 25(1):5-8.

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Abstract

The process of gene expression has material costs caused by the quantities of carbon, nitrogen, sulfur and phosphorus that are needed to make mRNAs and proteins. When any such chemical element is ecologically limiting, mutations increasing these costs can reduce growth. Here, we ask if such mutations are 'visible' to natural selection in the yeast Saccharomyces cerevisiae. We find that mutations causing small increases in expression and even single amino acid replacements can be subject to natural selection on the basis of their material costs.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Department of Biochemistry
07 Faculty of Science > Department of Biochemistry

Special Collections > SystemsX.ch
Special Collections > SystemsX.ch > Research, Technology and Development Projects > YeastX
DDC:570 Life sciences; biology
Language:English
Date:January 2009
Deposited On:08 Jan 2009 11:10
Last Modified:28 Nov 2013 00:32
Publisher:Elsevier
ISSN:0168-9525
Publisher DOI:10.1016/j.tig.2008.10.007
PubMed ID:19010565
Citations:Web of Science®. Times Cited: 23
Google Scholar™
Scopus®. Citation Count: 23

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