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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-984

Ruberte, E; Marty, T; Nellen, D; Affolter, M; Basler, K (1995). An absolute requirement for both the type II and type I receptors, punt and thick veins, for dpp signaling in vivo. Cell, 80(6):889-897.

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Abstract

TGF beta elicits diverse cellular responses by signaling through receptor complexes formed by two distantly related transmembrane serine/threonine kinases called type II and type I receptors. Previous studies have indicated that the product of the Drosophila thick veins (tkv) gene is a type I receptor for decapentaplegic (dpp). Here, we show that the Drosophila gene punt encodes a homolog of a vertebrate type II receptor, and we demonstrate that punt, like tkv, is essential in vivo for dpp-dependent patterning processes. Because no dpp-related signalling is apparent in the absence of either the punt or tkv receptor, we infer that both receptors act in concert to transduce the dpp signal and that their functions cannot be replaced by the other extant type II and I receptors.

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:24 March 1995
Deposited On:11 Feb 2008 12:19
Last Modified:27 Nov 2013 23:44
Publisher:Elsevier
ISSN:0092-8674
Publisher DOI:10.1016/0092-8674(95)90292-9
PubMed ID:7697719
Citations:Web of Science®. Times Cited: 216
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