Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-985

Nellen, D; Affolter, M; Basler, K (1994). Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic. Cell, 78(2):225-237.

[img]
Preview
PDF
7Mb

Abstract

Members of the TGF beta superfamily of secreted signaling molecules regulate growth and cellular patterning during development and interact with specific type I and type II membrane receptors possessing a cytoplasmic serine/threonine kinase domain. We describe two members of the type I receptor family in Drosophila and demonstrate that they are encoded by the genes saxophone (sax) and thick veins (tkv). Further, we show that mutations that abolish sax or tkv activity cause phenotypes similar to partial or complete loss of activity, respectively, of the TGF beta homolog decapentaplegic (dpp). We propose that specification of distinct cell fates in response to different concentrations of dpp may be achieved combinatorially by the sax and tkv receptors.

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:29 July 1994
Deposited On:11 Feb 2008 13:19
Last Modified:27 Nov 2013 23:20
Publisher:Elsevier
ISSN:0092-8674
Publisher DOI:10.1016/0092-8674(94)90293-3
PubMed ID:8044837
Citations:Web of Science®. Times Cited: 218
Google Scholar™

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page