Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-986
Basler, K; Edlund, T; Jessell, T M; Yamada, T (1993). Control of cell pattern in the neural tube: regulation of cell differentiation by dorsalin-1, a novel TGF beta family member. Cell, 73(4):687-702.
View at publisher
Distinct cell types differentiate along the dorsoventral axis of the neural tube. We have cloned and characterized a novel member of the TGF beta gene family, dorsalin-1 (dsl-1), that appears to regulate cell differentiation within the neural tube. dsl-1 is expressed selectively in the dorsal neural tube, and its pattern of expression appears to be restricted by early signals from the notochord. Exposure of neural plate cells to dsl-1 promotes the differentiation of cells with neural crest-like properties and inhibits the induction of motor neurons by signals from the notochord and floor plate. These findings suggest that dsl-1 regulates the differentiation of cell types along the dorsoventral axis of the neural tube, acting in conjunction with distinct ventralizing signals from the notochord and floor plate.
90 downloads since deposited on 11 Feb 2008
19 downloads since 12 months
|Item Type:||Journal Article, refereed|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|Dewey Decimal Classification:||570 Life sciences; biology|
|Date:||21 May 1993|
|Deposited On:||11 Feb 2008 12:19|
|Last Modified:||09 Dec 2013 20:38|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page