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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-986

Basler, K; Edlund, T; Jessell, T M; Yamada, T (1993). Control of cell pattern in the neural tube: regulation of cell differentiation by dorsalin-1, a novel TGF beta family member. Cell, 73(4):687-702.



Distinct cell types differentiate along the dorsoventral axis of the neural tube. We have cloned and characterized a novel member of the TGF beta gene family, dorsalin-1 (dsl-1), that appears to regulate cell differentiation within the neural tube. dsl-1 is expressed selectively in the dorsal neural tube, and its pattern of expression appears to be restricted by early signals from the notochord. Exposure of neural plate cells to dsl-1 promotes the differentiation of cells with neural crest-like properties and inhibits the induction of motor neurons by signals from the notochord and floor plate. These findings suggest that dsl-1 regulates the differentiation of cell types along the dorsoventral axis of the neural tube, acting in conjunction with distinct ventralizing signals from the notochord and floor plate.

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Date:21 May 1993
Deposited On:11 Feb 2008 12:19
Last Modified:09 Dec 2013 20:38
Publisher DOI:10.1016/0092-8674(93)90249-P
PubMed ID:7916656
Citations:Web of Science®. Times Cited: 305
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